✉news ScienceBiology first seen 11 h ago, last 7 h ago, peak #37

Study maps rational selection of adenine base editors for human genome editing

Original: Rational selection of SpCas9 and variant-derived adenine base editors for human genome editing

A Nature publication describes a rational framework for choosing between SpCas9 and variant-derived adenine base editors when editing the human genome. The work aims to help researchers match editor choice to specific target sites and desired edits, improving precision in gene-editing applications. The paper is being circulated among readers following advances in CRISPR-based genome editing tools.

Why now: New guidance on selecting CRISPR base editors is relevant to researchers working on precise human genome editing.

NatureSpCas9adenine base editors

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Evidence

• Rational selection of SpCas9 and variant-derived adenine base editors for human genome editing · Nature

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