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p53
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- 1p53 shown to prevent chromothripsis by balancing transcription and replication●p53 keeps a transcription–replication balance that prevents chromothripsis
A report in Nature describes how the p53 tumour suppressor maintains a balance between transcription and DNA replication, and that this balance prevents chromothripsis, the catastrophic shattering of chromosomes seen in many cancers. The finding links a classic cancer-protective protein to a specific mechanism guarding genome integrity, and is drawing attention from researchers studying how tumours arise.