{"ok":true,"trend":{"id":800994,"platform":"news","region":"global","key":"transcription remodeling and stalling by cisplatin-induced interstrand crosslinks","title":"Transcription remodeling and stalling by cisplatin-induced interstrand crosslinks","url":"https://news.google.com/rss/articles/CBMiX0FVX3lxTFAyTlJWMEI1V3RXYUd5OG9YLTlSOVJJQ1BmbzVseG1ONTBMMFZ0UkdvRmZwM1NleDF5NndRTWpjV28yb3U5M3E4S05yU0pCME9fWkdGd3M5dkd2T3ItSlNJ?oc=5","first_seen":"2026-10-03T01:24:51.261830Z","last_seen":"2026-10-03T09:36:51.726920Z","last_rank":24,"peak_rank":19,"last_volume":null,"peak_volume":0,"seen_count":7,"score":0.565625,"category_hint":"biology","section":"science","category":"biology","summary":"A study published in Nature examines how cisplatin-induced interstrand crosslinks affect transcription, showing how these DNA lesions remodel and stall the transcription machinery as it encounters the damage. Cisplatin is a widely used chemotherapy drug, and understanding how its crosslinks block RNA polymerase progression provides insight into the drug's mechanism of action and how cells respond to such DNA damage.","why":"New molecular-level findings on how a major chemotherapy drug damages and blocks transcription are of interest to cancer and DNA repair researchers.","tone":"neutral","entities":["cisplatin","Nature"],"summarized_at":"2026-10-03T07:28:55.841071Z","meta":{"via":"scan","lang":"en","term":"biology","source":"Nature","published":"Fri, 02 Oct 2026 10:32:01 GMT"},"nw":null,"promo":null,"kind":null,"importance":null,"hidden":false,"hide_reason":null,"judged_at":null,"title_en":"Study reveals how cisplatin crosslinks stall transcription","section_name":"Science","category_name":"Biology","timeline":[{"captured_at":"2026-10-03T01:24:51.261830Z","rank":20,"volume":null},{"captured_at":"2026-10-03T02:46:13.875223Z","rank":19,"volume":null},{"captured_at":"2026-10-03T04:08:30.817100Z","rank":20,"volume":null},{"captured_at":"2026-10-03T05:30:39.590249Z","rank":19,"volume":null},{"captured_at":"2026-10-03T06:52:31.391965Z","rank":20,"volume":null},{"captured_at":"2026-10-03T08:14:30.152056Z","rank":20,"volume":null},{"captured_at":"2026-10-03T09:36:51.726920Z","rank":24,"volume":null}],"posts":[{"platform":"news","url":"https://news.google.com/rss/articles/CBMiX0FVX3lxTFAyTlJWMEI1V3RXYUd5OG9YLTlSOVJJQ1BmbzVseG1ONTBMMFZ0UkdvRmZwM1NleDF5NndRTWpjV28yb3U5M3E4S05yU0pCME9fWkdGd3M5dkd2T3ItSlNJ?oc=5","author":"Nature","title":"Transcription remodeling and stalling by cisplatin-induced interstrand crosslinks","snippet":null,"posted_at":"2026-10-02T10:32:01Z","likes":null}],"elsewhere":[],"window":"7d"}}