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microsatellite instability cancers
Trends
- 1New synthetic lethal drug targets microsatellite instability cancers▼A synthetic lethal drug for microsatellite instability cancers
Researchers have reported the development of a synthetic lethal drug aimed at cancers with microsatellite instability, a genetic feature found in colorectal and other tumor types. Synthetic lethality exploits mutations unique to cancer cells, sparing healthy tissue. The work was published in Nature, and scientists say such drugs could expand treatment options for patients whose tumors resist existing immunotherapies.
- 2Phase 1 trial tests Werner helicase inhibitor in MSI tumors▼Werner helicase inhibitor for advanced microsatellite instability solid tumors: a phase 1 trial
A phase 1 clinical trial is testing a Werner helicase inhibitor in patients with advanced microsatellite instability-high solid tumors, according to a report published in Nature. The approach targets a DNA repair vulnerability in these cancers, which often resist standard therapies. Early-stage results will determine safety, dosing and whether the drug warrants further development.