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chromothripsis
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- 1p53 shown to prevent chromothripsis by balancing transcription and replication●p53 keeps a transcription–replication balance that prevents chromothripsis
Research published in Nature reports that the p53 tumour suppressor protein maintains a balance between transcription and DNA replication, and that this balance prevents chromothripsis, a catastrophic form of chromosome shattering linked to cancer. The finding adds to understanding of how p53 suppresses tumours beyond its established roles in cell-cycle control and apoptosis, and highlights genome instability mechanisms relevant to cancer research.